Our Research Interests

A broad range of physiological functions exhibits daily variations, such as the sleep/wake cycle, the endocrine system, and metabolism, which are precisely controlled by molecular circadian clocks. Importantly, genetic deletion of the circadian clock components results in robust phenotypes related to metabolic disorders and premature aging, while simultaneously the circadian clock functions are reprogrammed by metabolic and epigenetic modifications. Molecular insights into how the circadian clock affiliates with metabolism underscore the interaction between disrupted circadian clockwork, abnormal behavioral rhythms, and metabolic diseases.

This points to a potential strategy for the promotion of metabolic health and the treatment of metabolic diseases through systemic and local activation of the circadian regulation of homeostasis.

This notion is strongly supported by mounting evidence indicating that dietary intervention exerts beneficial impacts on the circadian core clock machinery and thus clock-controlled metabolic pathways.
Undoubtedly, the prevention and treatment of metabolic diseases are placed as a crucial health problem.